Racial and Ethnic profile in the Hypertension risk related to Serum Calcium and Insulin Resistance: A study comparison between a multiracial and a single race population

Abstract

Background

Recent researches suggest assessing more ethnic disparities in hypertension (HTN). On the other hand, studies reveal impressive mortality rates due to cardiovascular diseases for some breeds compared to others.

Method

We referred to a recent survey on Serum Calcium (SC) and Insulin Resistance associated with HTN incidence to compare different Race groups in the latter found relationship. We compare the current study outcomes with those from the Wu and colleagues study (BS).

Results

From 425 participants to the National Health And Nutrition Examination Survey (NHANES) data, we found a significant association between Race and Hypertension; Cramer’s V (0.006) = 0.21 when adjusted with Nonhypertensives and Hypertensives. Mc Auley index (McA) was negatively related to hypertension, r (355) = -0.24, p < 0.0001. SC associated with HTN in all race groups significance persisted only in Non-Hispanic Whites after multivariate adjustments R2 of 74.1 (p = 0.03). McA was a mediator on SC-HTN in NHW (CoefIE = 13.25, [CI] = 1.42-32.13), and a moderator in Other Hispanics Interaction (0.04) = 0.27 and NHW Interaction (0.001) = 0.028.

Conclusion

SC was associated with hypertension, similarly to the BS. SC and HTN association persisted in NHW compare to other race groups. HOMA-IR was not a mediator on SC - HTN, but with McA, this in NHW only. McA played a moderator role in OH and NHW. We suggest race factor implicated in our findings, which further researches may investigate.

Keywords: Race, Serum Calcium, Mc Auley index, HOMA-IR, Hypertension incidence