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Mother’s Significant Feature (MSF) Dataset has been designed to provide data to researchers working towards woman and child health betterment. MSF dataset records are collected from the Mumbai metropolitan region in Maharashtra, India. Women were interviewed just after childbirth between February 2018 to March 2021. MSF comprise of 450 records with a total of 130 attributes consisting of mother’s features, father’s features and health outcomes. A detailed dataset is created to understand the mother’s features spread across three phases of her reproductive age i.e.